Sildenafil - kev ua, indications, contraindications, phiv

Sildenafil yog ib qho tshuaj siv los kho erectile kawg. Nws yog thawj zaug sau rau cov neeg mob pulmonary hypertension, tab sis nws cov txiaj ntsig ntawm kev sib deev tau pom sai sai. Tam sim no nws yog ib qho tshuaj tsis tu ncua rau cov txiv neej uas tawm tsam nrog qhov teeb meem ntawm impotence. Dab tsi koj yuav tsum paub txog Sildenafil?

1. Sildenafil yog dab tsi?

Cov tshuaj tseem ceeb rau kev kho erectile kawg yog phosphodiesterase type 5 inhibitors (PDE-XNUMX). Cov tshuaj nto moo tshaj plaws ntawm hom no yog Viagra.

Nws yog thawj zaug qhia hauv 1998 rau Asmeskas kev lag luam thiab txij li ntawd tau muaj nyob rau txhua qhov chaw hauv ntiaj teb. Txawm li cas los xij, nws yuav tsum nco ntsoov tias muaj ntau yam tshuaj ntxiv nrog tib lub tswv yim ntawm kev ua. Lub nto moo tshaj plaws:

• Sildenafil
• tadalafil,
• Vardenafil.

Kev taw qhia ntawm Sildenafil thiab tag nrho cov tshuaj ntawm cov pab pawg no yog random heev. Thaum xub thawj, sildenafil tau muab tshuaj rau cov neeg mob pulmonary arterial hypertension. Nws erection li nyhuv tau pom sai sai los ntawm cov neeg mob, uas ua rau muaj kev hloov pauv hauv cov lus qhia rau kev siv cov tshuaj no.

Ua ntej lub caij nyoog ntawm sildenafil, cov txiv neej tau siv thiab feem ntau siv ntau lwm tus, qhov thiaj li hu ua nrov, tshwj xeeb. Nws muaj kev nyab xeeb hais tias hauv txhua kab lis kev cai muaj qee yam khoom uas yuav tsum txhim kho potency. Thiab yog, tib neeg tau siv cov kev kho mob hauv qab no rau erectile kawg rau ntau pua xyoo:

• rhino horn hmoov yog nrov heev nyob rau hauv Suav teb,
• Hauv lwm haiv neeg nws yog cov ntshav ntawm ib tug puav, cov noob qes ntawm hma liab thiab mos lwj, lub hlwb ntawm miv,
• wormwood, verbena, qhiav, qej, lovage, nutmeg, cloves.

Nws yuav tsum tau hais tias feem ntau ntawm cov tshuaj no tsis muaj pov thawj mechanism ntawm kev ua. Lawv txoj kev ua tau zoo yog nyob ntawm kev ntseeg tej yam yees siv hauv lawv qhov kev ua.

2. Sildenafil ua haujlwm li cas

Sildenafil yog thawj patented hauv 1996 thiab ntaus lub lag luam ob xyoos tom qab. Tam sim no, nws yog ib qho tshuaj rau potency, nrog thawj pulmonary hypertension (III functional class) thiab nrog qee cov kab mob ntawm cov ntaub so ntswg.

Cov tshuaj muaj 25-100 milligrams ntawm sildenafil citrate. Sildenafil muaj nyob rau hauv nws cov qauv piperazine motif thiab guanine analog, 1H-pyrazolo [4,3-d]pyrimidine. Lub hauv paus phenol system yog structurally sib npaug rau ribose, thiab cov sulfone residue sib haum mus rau phosphate pawg ntawm nucleotide.

Qhov sib xyaw no hauv lub cev inhibits feem ntau phosphodiesterase hom 5 (PDE5) - qhov kev sib raug zoo rau lwm hom enzyme no qis dua. PDE5 cleaves cGMP, uas yog lub luag hauj lwm rau so kom txaus cov nqaij ntshiv thiab ua kom cov ntshav ntws mus rau lub cev cavernous.

Thaum muaj kev sib deev stimulation, paj hlwb pib tsim nitric oxide (NO), uas ua rau nws muaj peev xwm siv cGMP. Thaiv los ntawm sildenafil, PDE5 tso cai rau koj kom "tswj" ib qho erection.

Txawm li cas los xij, nyob rau hauv ntau tus txiv neej, vim neurosis, kev nyuaj siab, hormonal imbalance, los yog kev puas tsuaj ntawm lub sympathetic paj hlwb, zus tau tej cov nitric oxide los ntawm paj hlwb tsis muaj zog, uas ua rau tsis muaj zog thiab luv luv erections. Qhov nqus sai tshaj plaws tshwm sim tom qab noj cov tshuaj ntawm lub plab khoob. Nws raug tshem tawm feem ntau nrog cov quav (kwv yees li 80%) thiab qis dua nrog cov zis.

3. Cov lus qhia rau kev siv Sildenafil

Kaum tshuaj rau potency tso cai rau cov txiv neej kom ua tiav erection mus tas li thiab muaj kev sib deev. Qhov zoo ntawm cov tshuaj no yog qhov tseeb tias qhov erection tsis tshwm sim tam sim ntawd tom qab noj tshuaj, tab sis yuav tsum muaj kev sib deev stimulation (tsis zoo li cov tshuaj prostaglandin).

Cov tshuaj raug pom zoo kom noj ib mus rau rau teev ua ntej kev sib deev tau npaj tseg. Tom qab tus kws kho mob soj ntsuam cov degree thiab qhov xwm ntawm impotence, tus kws kho mob xaiv cov koob tshuaj (25, 50 lossis 100 mg), uas tso cai rau koj kom tswj tau qhov erection ntawm 30 feeb mus rau ib teev. Cov tshuaj tau pom zoo kom noj ib hnub ib zaug. Rau cov neeg uas muaj lub raum tsis txaus, kev txo koob tshuaj yog pom zoo.

4. Contraindications

Cov tshuaj no yuav tsum tsis txhob noj los ntawm cov txiv neej nyob rau hauv cov xwm txheej hauv qab no:

• kab mob coronary artery,
• malignant hypertension,
• circulatory failure (NYHA class III and IV),
• nrog lub plawv nres tsis ntev los no (thawj ob lub lis piam),
• obstructive cardiomyopathy
• nrog ventricular arrhythmias (malignant, tshwm sim los ntawm kev tawm dag zog, kev ntxhov siab, kev xav),
• nrog cov kab mob valvular hnyav
• mob siab heev thiab lub raum tsis ua haujlwm,
• tom qab mob stroke
• nrog degenerative hloov nyob rau hauv lub retina (piv txwv li, retinitis pigmentosa),
• hypotension,
• nrog hypersensitivity rau cov khoom ntawm cov tshuaj.

Siledenafil Nws muaj cov nyhuv vasodilatory thiab tuaj yeem ua rau muaj kev phom sij rau cov neeg siv tshuaj kho mob plawv thiab vascular. Ib qho contraindications rau kev noj tshuaj yog noj Nitrate thiab Molsidomine.

Qhov sib txawv ntawm cov metabolism ntawm cov tshuaj no kuj yuav tsum tau coj mus rau hauv tus account. Nws raug rhuav tshem hauv daim siab, uas txhais tau hais tias kev tso tawm ntawm cov tshuaj no txo ​​qis hauv cov neeg uas muaj daim siab puas thiab muaj hnub nyoog tshaj 65 xyoo, thiab cov koob tshuaj ntau dua tuaj yeem ua rau muaj kev phom sij. Cov tshuaj paub tias cuam tshuam nrog siledenafil muaj xws li:

• assimilate,
• erythromycin,
• ketoconazole,
• rifampicin thiab lwm yam.

Sildenafil, vim yog vasodilating mechanism, txo cov ntshav siab. Txog niaj hnub no, kev tuag los ntawm kev siv sildenafil tau tshwm sim hauv cov neeg siv cov tshuaj tiv thaiv kab mob plawv, xws li, piv txwv li, nitrates lossis lwm yam. tshuaj kom txo cov ntshav siab.

Cov tshuaj no tsis pom zoo rau impotence rau cov txiv neej hnub nyoog qis dua 18 xyoo thiab rau qhov tsis xws luag ntawm qhov chaw mos (xws li flexure, cavernous fibrosis lossis Peyronie's disease) tom qab noov prosthesis thiab nrog cov xwm txheej uas ua rau lawv mus rau priapism (piv txwv li, mob cell anemia, ntau yam myeloma, lossis leukemia). Cov tshuaj tsis yog siv los ua ib feem ntawm kev sib xyaw ua ke rau kev kho mob erectile kawg.

5. Kev mob tshwm sim tom qab noj sildenafil

Sildenafil yog ib qho tshuaj tiv thaiv zoo los ntawm cov txiv neej feem ntau. Txawm li cas los xij Cov teebmeem ntawm sildenafil, Cov no suav nrog:

• mob taub hau thiab kiv taub hau
• liab ntawm lub ntsej muag
• dyspepsia (mob plab),
• qhov muag tsis pom kev).

Cov kev mob tshwm sim tsawg dua ntawm kev noj siledenafil yog:

• o ntawm qhov ntswg mucosa,
• kab mob ntawm lub zais zis thiab urethra,
• mob nqaij thiab pob qij txha.

Cov kev mob tshwm sim saum toj no ntawm sildenafil tau tshaj tawm los ntawm kwv yees li 35 feem pua. Cov neeg mob. Cov tsos mob ntawm cov tsos mob no cuam tshuam nrog kev thaiv PDE hom 5, nrog rau lwm yam hauv qee lub cev. Cov neeg uas muaj lub plawv dhia txawv txav, ntshav siab, thiab nyiam ua rau lub plawv nres tuaj yeem ntsib teeb meem loj, suav nrog myocardial infarction thiab tuag (vim tso tawm nitric oxide).

Kev siv tshuaj los ntawm cov txiv neej noj qab haus huv tuaj yeem ua rau muaj teeb meem ntxiv rau kev ua tiav erection (tsis siv tshuaj), mob o ntawm noov, o thiab kev puas tsuaj ntawm lub cev cavernous.

Kev noj ntau dhau tuaj yeem ua kom erection mus txog 6 teev. Vim tias muaj peev xwm ua rau pom kev tsis pom kev thiab kiv taub hau tom qab noj tshuaj, koj yuav tsum tsis txhob tsav tsheb thiab ua haujlwm nrog cov txheej txheem.

6. Ua rau impotence

Impotence (ED) txhais tau tias yog "kev sib deev tsis zoo uas tshwm sim tsis muaj erection los yog ejaculate txawm excitement thiab txaus siab rau foreplay. " Impotence tsis yog qhov tsis muaj erection thaum sib deev xws li kev sib deev, uas feem ntau yog nrog kev ntxhov siab.

Peb tuaj yeem tham txog kev mob nkeeg thaum twg teeb meem erection thiab ejaculation tshwm sim ntau zaus, txawm tias muaj kev sib txuas ntawm cov neeg koom tes. Tus kab mob no tuaj yeem muab faib ua thawj thiab theem nrab (tshwm sim tom qab lub sijhawm ntawm kev sib deev ib txwm muaj).

Lub hauv paus ua rau muaj teeb meem hauv lub neej kev sib deev tag nrho tuaj yeem yog lub hlwb (psychogenic impotence) thiab organic (somatic) yam.

Thawj pab pawg muaj xws li: ntshai kev sib deev, ntshai tsis xav cev xeeb tub, complexes, ua txhaum, kev txhaum, kev ntxhov siab, kev puas siab puas ntsws kev loj hlob, introversion (xav kom tsom ntsoov rau tus kheej). Feem ntau nyob rau hauv cov xwm txheej zoo li no, thaum pw tsaug zog lossis masturbation, kev tshwm sim yog qhov qub.

Lub cev ua rau lub cev tsis muaj zog muaj xws li cov kab mob (mob ntshav qab zib mellitus, ntau yam sclerosis, tetraplegia, ALS, lub plawv tsis xws luag, mob ntshav siab hnyav, phimosis, dej ntws, Peyronie's disease) lossis kev hloov pauv hnub nyoog (andropause) uas tiv thaiv erections. Qee cov tshuaj stimulants (cawv, amphetamines) thiab tshuaj (SSRIs, SNRIs) kuj tuaj yeem ua rau impotence.

Txaus siab rau cov kev pab kho mob yam tsis muaj kab. Teem sijhawm nrog ib tus kws kho mob tshwj xeeb nrog e-muab tshuaj thiab e-daim ntawv pov thawj lossis kev kuaj mob ntawm abcHealth Nrhiav tus kws kho mob.